We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies, revised Privacy Policy and Terms of Service.
You are being directed to ZacksTrade, a division of LBMZ Securities and licensed broker-dealer. ZacksTrade and Zacks.com are separate companies. The web link between the two companies is not a solicitation or offer to invest in a particular security or type of security. ZacksTrade does not endorse or adopt any particular investment strategy, any analyst opinion/rating/report or any approach to evaluating individual securities.
If you wish to go to ZacksTrade, click OK. If you do not, click Cancel.
Alnylam Stock Up on Favorable Patisiran and Revusiran Data
Read MoreHide Full Article
Alnylam Pharmaceuticals, Inc.’s (ALNY - Free Report) shares jumped 10.7% after the company announced preliminary results from the ongoing phase II open-label extension (OLE) studies on its pipeline candidates, patisiran and revusiran. Data are being presented at the XV International Symposium on Amyloidosis.
We note that both patisiran and revusiran are experimental RNAi therapeutics targeting transthyretin (TTR) and are being evaluated for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis).
Data from the single-arm phase II OLE study showed that following 24 months of treatment with patisiran, hATTR patients with polyneuropathy (hATTR-PN; also known as familial amyloidotic polyneuropathy) witnessed improvement or no change in the mean neuropathy impairment score. Overall, these data support the therapeutic hypothesis that reduction of mutant and wild-type TTR with patisiran has the potential to halt or improve neuropathy progression in patients with hATTR-PN.
Alnylam also presented baseline demographics from the APOLLO phase III study on patisiran in hATTR-PN patients, which showed that a significant number of patients (54%) demonstrated evidence of cardiac disease. The company believes this patient subset should allow for a controlled evaluation of effects of patisiran on cardiac parameters. Alnylam expects to report data from the APOLLO study in mid-2017.
In addition, initial 12-month data from the phase II OLE study revealed that revusiran continued to show robust and sustained knockdown of serum TTR. Moreover, 6-minute walk distance results were found to be generally stable in the majority of evaluable hATTR patients with cardiomyopathy (also known as familial amyloidotic cardiomyopathy).
Alnylam also announced that it expects to complete enrollment in the ENDEAVOUR phase III study on revusiran this summer, ahead of schedule. Data readout is now anticipated in early 2018. Previously, the company had expected to complete enrollment in the study in late 2016 while results were projected in mid-2018.
Considering that Alnylam has no approved product in its portfolio, successful development of both patisiran and revusiran is crucial for the company. We expect investor focus to remain on updates pertaining to their development.
Alnylam is a Zacks Rank #3 (Hold) stock. Some better-ranked stocks in the healthcare sector include ANI Pharmaceuticals, Inc. (ANIP - Free Report) , Innoviva, Inc. (INVA - Free Report) and Pfizer Inc. (PFE - Free Report) . While ANI Pharmaceuticals and Innoviva are Zacks Rank #1 (Strong Buy) stocks, Pfizer sports a Zacks Rank #2 (Buy).
Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report >>
See More Zacks Research for These Tickers
Normally $25 each - click below to receive one report FREE:
Image: Bigstock
Alnylam Stock Up on Favorable Patisiran and Revusiran Data
Alnylam Pharmaceuticals, Inc.’s (ALNY - Free Report) shares jumped 10.7% after the company announced preliminary results from the ongoing phase II open-label extension (OLE) studies on its pipeline candidates, patisiran and revusiran. Data are being presented at the XV International Symposium on Amyloidosis.
We note that both patisiran and revusiran are experimental RNAi therapeutics targeting transthyretin (TTR) and are being evaluated for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis).
Data from the single-arm phase II OLE study showed that following 24 months of treatment with patisiran, hATTR patients with polyneuropathy (hATTR-PN; also known as familial amyloidotic polyneuropathy) witnessed improvement or no change in the mean neuropathy impairment score. Overall, these data support the therapeutic hypothesis that reduction of mutant and wild-type TTR with patisiran has the potential to halt or improve neuropathy progression in patients with hATTR-PN.
Alnylam also presented baseline demographics from the APOLLO phase III study on patisiran in hATTR-PN patients, which showed that a significant number of patients (54%) demonstrated evidence of cardiac disease. The company believes this patient subset should allow for a controlled evaluation of effects of patisiran on cardiac parameters. Alnylam expects to report data from the APOLLO study in mid-2017.
In addition, initial 12-month data from the phase II OLE study revealed that revusiran continued to show robust and sustained knockdown of serum TTR. Moreover, 6-minute walk distance results were found to be generally stable in the majority of evaluable hATTR patients with cardiomyopathy (also known as familial amyloidotic cardiomyopathy).
Alnylam also announced that it expects to complete enrollment in the ENDEAVOUR phase III study on revusiran this summer, ahead of schedule. Data readout is now anticipated in early 2018. Previously, the company had expected to complete enrollment in the study in late 2016 while results were projected in mid-2018.
Considering that Alnylam has no approved product in its portfolio, successful development of both patisiran and revusiran is crucial for the company. We expect investor focus to remain on updates pertaining to their development.
Alnylam is a Zacks Rank #3 (Hold) stock. Some better-ranked stocks in the healthcare sector include ANI Pharmaceuticals, Inc. (ANIP - Free Report) , Innoviva, Inc. (INVA - Free Report) and Pfizer Inc. (PFE - Free Report) . While ANI Pharmaceuticals and Innoviva are Zacks Rank #1 (Strong Buy) stocks, Pfizer sports a Zacks Rank #2 (Buy).
Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report >>